770 research outputs found
Beyond Patient Reported Pain: Perfusion Magnetic Resonance Imaging Demonstrates Reproducible Cerebral Representation of Ongoing Post-Surgical Pain
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Skyrmion Excitation in Two-Dimensional Spinor Bose-Einstein Condensate
We study the properties of coreless vortices(skyrmion) in spinor
Bose-Einstein condensate. We find that this excitation is always energetically
unstable, it always decays to an uniform spin texture. We obtain the skyrmion
energy as a function of its size and position, a key quantity in understanding
the decay process. We also point out that the decay rate of a skyrmion with
high winding number will be slower. The interaction between skyrmions and other
excitation modes are also discussed.Comment: 5 pages, 4 figures, final version published in Phys. Rev.
Customised, Individualised Treatment of Metastatic Non-Small-Cell Lung Carcinoma (NSCLC)
A series of phase II and randomised phase III trials in Asia and Europe have confirmed recently that advanced stage non-small-cell lung carcinoma patients with adenocarcinoma subtypes harbouring specific mutations when subjected to targeted therapy experience equivalent survival outcomes as those treated with chemotherapy and are spared from its side effects. The concept of chemotherapy for all is fading, and therapy optimisation has emerged as a paradigm shift in treatment. This article briefly describes cellular mechanisms involved in lung carcinogenesis which provide a molecular basis for targeted therapy. Advances in molecular biology have improved our understanding of mechanisms involved in primary or secondary drug resistance. Evolving biomarkers of prognostic and predictive importance, and the impact of translational research on outcomes are also covered. A marker is considered prognostic if it predicts the outcome, regardless of the treatment, and predictive if it predicts the outcome of a specific therapy
Dimensional and Temperature Crossover in Trapped Bose Gases
We investigate the long-range phase coherence of homogeneous and trapped Bose
gases as a function of the geometry of the trap, the temperature, and the
mean-field interactions in the weakly interacting limit. We explicitly take
into account the (quasi)condensate depletion due to quantum and thermal
fluctuations, i.e., we include the effects of both phase and density
fluctuations. In particular, we determine the phase diagram of the gas by
calculating the off-diagonal one-particle density matrix and discuss the
various crossovers that occur in this phase diagram and the feasibility of
their experimental observation in trapped Bose gases.Comment: One figure added, typos corrected, refernces adde
Damped Bogoliubov excitations of a condensate interacting with a static thermal cloud
We calculate the damping of condensate collective excitations at finite
temperatures arising from the lack of equilibrium between the condensate and
thermal atoms. We neglect the non-condensate dynamics by fixing the thermal
cloud in static equilibrium. We derive a set of generalized Bogoliubov
equations for finite temperatures that contain an explicit damping term due to
collisional exchange of atoms between the two components. We have numerically
solved these Bogoliubov equations to obtain the temperature dependence of the
damping of the condensate modes in a harmonic trap. We compare these results
with our recent work based on the Thomas-Fermi approximation.Comment: 9 pages, 3 figures included. Submitted to PR
The Surface of a Bose-Einstein Condensed Atomic Cloud
We investigate the structure and collective modes of a planar surface of a
trapped Bose-Einstein condensed gas at zero temperature. In the long-wavelength
limit we find a mode similar to the gravity wave on the surface of a fluid with
the frequency and the wavenumber related by . Here
is the force due to the confining potential at the surface and is the
particle mass. At shorter wavelengths we use a variational approach and find
corrections to of order . We demonstrate the usefulness
of the concept of an effective surface tension for describing both static and
dynamic properties of condensed atomic clouds.Comment: 8 pages, REVTEX, submitted to Phys. Rev.
Association study of two interleukin-1 gene loci with essential hypertension in a Pakistani Pathan population
An association study of IL-1 beta -511C/T and IL-1 RN 86 bp VNTR polymorphisms with essential hypertension was carried out in a sample population of 500 Pakistani Pathan subjects selected randomly, comprising groups of 235 subjects with hypertension and 265 controls. The distribution of both genotypes and alleles was not statistically different in cases and controls. In conclusion, IL-1 beta -511C/T and IL-1 RN 86 bp VNTR do not contribute to the aetiology of essential hypertension in the Pakistani Pathan population investigated here
Micron-sized atom traps made from magneto-optical thin films
We have produced magnetic patterns suitable for trapping and manipulating
neutral atoms on a m length scale. The required patterns are made in
Co/Pt thin films on a silicon substrate, using the heat from a focussed laser
beam to induce controlled domain reversal. In this way we draw lines and
"paint" shaped areas of reversed magnetization with sub-micron resolution.
These structures produce magnetic microtraps above the surface that are
suitable for holding rubidium atoms with trap frequencies as high as ~1 MHz.Comment: 6 pages, 7 figure
Five-year review of an international clinical research-training program
The exponential increase in clinical research has profoundly changed medical sciences. Evidence that has accumulated in the past three decades from clinical trials has led to the proposal that clinical care should not be based solely on clinical expertise and patient values, and should integrate robust data from systematic research. As a consequence, clinical research has become more complex and methods have become more rigorous, and evidence is usually not easily translated into clinical practice. Therefore, the instruction of clinical research methods for scientists and clinicians must adapt to this new reality. To address this challenge, a global distance-learning clinical research-training program was developed, based on collaborative learning, the pedagogical goal of which was to develop critical thinking skills in clinical research. We describe and analyze the challenges and possible solutions of this course after 5 years of experience (2008-2012) with this program. Through evaluation by students and faculty, we identified and reviewed the following challenges of our program: 1) student engagement and motivation, 2) impact of heterogeneous audience on learning, 3) learning in large groups, 4) enhancing group learning, 5) enhancing social presence, 6) dropouts, 7) quality control, and 8) course management. We discuss these issues and potential alternatives with regard to our research and background
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